To further confirm that the activity of A1014907 is dependent on FGFR3 expression and not due to the presence of t(4;14) translocation, we examined the effect of A1014907 on two MM cell lines JIM2 and JIM3, both of which are t(4;14) cell lines but negative for FGFR3 expression. This evidence concerns the gene FGFR3 and Miyoshi myopathy.