It is important to point out that full target engagement was achieved in these in vivo experiments, based on our tumor immunophenotyping experiments showing greater than 90% suppression of cell surface CEACAM1 staining in CC1-treated animals and the fact that we maintained a plasma trough levels well above the receptor binding IC50 (at a dose of 30 mg/kg). The gene discussed is CEACAM1; the disease is neoplasm.