SIRT6 and Hypoglycemia: Consequently, reduced SIRT6 activity increases the acetylation and transcription rates of glycolytic genes, leading to enhanced glucose uptake and anaerobic glycolysis, to the point that SIRT6 deficient mice die from hypoglycemia shortly after birth due to abnormally high glucose uptake rates in skeletal muscle and brown adipose tissue (Mostoslavsky et al., 2006; Zhong et al., 2010).