As a consequence of the anti-FGF2/anti-angiogenic activity of PTX3, FGF2-dependent syngeneic tumor grafts of different origin were characterized by impaired FGFR1 activation and reduced CD31+ vascularization and tumor growth when injected in TgN(Tie2-hPTX3) mice (106). The gene discussed is PECAM1; the disease is neoplasm.