FGF2 and neoplasm: Indeed, due to its capacity to bind FGF8b, PTX3 prevents the interaction of this FGF family member with FGFR1 and blocks FGF8b-induced EC proliferation and chemotaxis in vitro and angiogenesis in vivo, causing a significant inhibition of tumor growth and vascularization when transduced in androgen-regulated Shionogi 115 mouse breast tumor cells (97) that express both FGF2 and FGF8b following stimulation with dihydrotestosterone (105).