Targeting the receptor VISTA (PD-1H), an Armenian hamster IgG prevented GVHD by tolerising effector T cells and selectively promoting regulatory T cell (Treg) expansion (57), whilst a mIgG1 VISTA agonist antibody suppressed acute inflammation in a model of Concanavalin-A induced hepatitis (46). The gene discussed is VSIR; the disease is graft versus host disease.