Given the fact that the aberrant NLRP3 inflammasome activation is involved in the pathology of various inflammatory disorders, including CAPS, gout, type 2 diabetes, obesity, as well as neurological diseases, what is the unified mechanism that modulates the NLRP3 activation in response to a wide spectrum of stimuli need to be further investigated. This evidence concerns the gene NLRP3 and obesity due to melanocortin 4 receptor deficiency.