Finally, the inhibition of a group of histone deacetylases, HDAC class IIa, by a specific inhibitor, TMP195, reduced tumor burden and pulmonary metastasis by modulating the TAM phenotype in the murine MMTV-PyMT breast cancer model, and enhanced chemo-and T-cell checkpoint blockade therapy (53). This evidence concerns the gene HDAC9 and neoplasm.