Similarly, a poly(lactic-co-glycolic acid) nanoparticle loaded with poly I:C and coated with a CD40 agonist antibody was directed toward CD40 expressing CD11c+CD11b+F4/80− DCs in vivo, resulting in prolonged survival of B16-OVA-tumor bearing mice (126). The gene discussed is ITGAM; the disease is neoplasm.