NNMT is involved in reorganizing the methylome in glioblastoma cells, as NNMT inhibition upregulates the availability of methyl groups that leucine carboxyl methyl transferase 1 uses to methylate protein phosphatase 2A, further inhibiting serine/threonine kinases (Palanichamy et al., 2017). This evidence concerns the gene NNMT and glioblastoma.