Moreover, NNMT dysregulation has been shown to be a contributing factor to the progression of gastric cancer, pancreatic cancer, prostate cancer, nasopharyngeal cancer, lung cancer, hepatocellular cancer, and renal cancer (Yao et al., 2005; Kim et al., 2009; Ujiie et al., 2012; Win et al., 2013; Bi et al., 2014; Zhou et al., 2014; Chen et al., 2016; Xu et al., 2016). Here, NNMT is linked to hepatocellular carcinoma.