Dyslipidemia can take part of the development and progression of renal disease in non-exercising conditions (i.e. lipid nephrotoxicity) (Gyebi et al., 2012) through inflammatory stress, oxidative stress, endoplasmic reticulum stress, endothelial dysfunction, and activation of the renin–angiotensin system (Ruan et al., 2009). The gene discussed is REN; the disease is endothelial dysfunction.