SNCA and dementia: Moreover, Iseki et al. (2001) found that ubiquitin-positive inclusions in the central nucleus of the amygdala of patient brains with dementia with Lewy bodies were also alpha-synuclein and tyrosine hydroxylase positive, suggesting that the degeneration of terminal axons of affected substantia nigra neurons were the source of the amygdala pathology in patients with dementia with Lewy bodies (Iseki et al., 2001).