Among the mGluRs, mGluR5 is one of the most studied receptor in various neurological disorders including chronic pain and mood disorders (Kolber, 2015; Pillai and Tipre, 2016; Sengmany and Gregory, 2016; Esterlis et al., 2018), given its known role in plastic changes in neural circuits (Bordi and Ugolini, 1999; Ribeiro et al., 2010). Here, GRM5 is linked to nervous system disorder.