Changes in expression of 13 out of 14 ankyrin repeats proteins in AD neurons with downregulated AnkRD18 and upregulated AnkRD34, increased ANK1 in PD microglia, elevated AnkRD36/ANKRD52/ANKRD18CP in AD astrocytes, and overexpressed Ankle2 in PD microglia suggest that this involvement is not disease specific but a process related to neuroinflammation. The gene discussed is ANKRD52; the disease is Alzheimer disease.