Conversely, cerebral amyloid angiopathy and insulin like growth factor binding protein 5 (IGFBP5) were only associated with APOE/TOMM40 SNPs (Figure 1, right lane), suggesting that the genetic effects of 457 SNPs on these variables are contingent on APOE/TOMM40. The gene discussed is APOE; the disease is cerebral amyloid angiopathy.