GBA1 and Parkinson disease: Rapamycin for example, has historically been used as an immunosuppressant agent, and is a well-established inducer of macroautophagy (Moors et al., 2017), and it has been shown to reduce α-synuclein accumulation in an in vitro model of GBA1 mutation-associated PD (Cullen et al., 2011).