In total, six genes were somatically mutated in two of the three PD-L1-positive ccRCC cases, including VHL, INADL, MUC4, RAD21, CSPG4 and BAP1. Both of the two PD-L1-positive PRCC cases contained somatic alterations in six other genes, namely, MACF1, DNAH7, DNAH11, TMPRSS13, CEP128 and GAN. In addition, TMPRSS13 was also somatically mutated in one ccRCC case. This evidence concerns the gene MACF1 and nonpapillary renal cell carcinoma.