It’s worth noting that the amino acid alterations p.P352fs and p.H193Q in BAP1, p.W1562C and p.S512X in SETD2, p.V343fs in PTEN and p.R882S in MTOR had not been reported previously in ccRCC, all of which were considered to be deleterious in this study. The gene discussed is MTOR; the disease is nonpapillary renal cell carcinoma.