VHL and nonpapillary renal cell carcinoma: In total, six genes were somatically mutated in two of the three PD-L1-positive ccRCC cases, including VHL, INADL, MUC4, RAD21, CSPG4 and BAP1. Both of the two PD-L1-positive PRCC cases contained somatic alterations in six other genes, namely, MACF1, DNAH7, DNAH11, TMPRSS13, CEP128 and GAN. In addition, TMPRSS13 was also somatically mutated in one ccRCC case.