Meanwhile, both ligand-dependent (co-expression of IHH-PTCH1) and independent inhibitors (SMO; PTCH1; GLI) may be considered as effective Hh signaling inhibitors in OS, while their effects has been shown in many cancers such as basal cell carcinoma and medulloblastoma [75, 76]. Here, PTCH1 is linked to basal cell carcinoma.