In support of its functional essentiality, RBX1 expression levels are inversely correlated with POLR2A in human prostate cancers (r = −0.45, TCGA), suggesting that loss of POLR2A in the 17ploss cells is probably compensated by the upregulated expression of RBX1 in prostate tumors. The gene discussed is RBX1; the disease is prostate cancer.