For example, the SUMO1-/sentrin-specific protease SENP1 has a pro-oncogenic role in several types of cancer (including pancreatic ductal adenocarcinoma (PDAC), prostate cancer, hepatocellular carcinoma, and metastatic neuroblastoma tissues), correlating with poor prognosis61–63. This evidence concerns the gene SENP1 and Familial prostate cancer.