For example, the SUMO1-/sentrin-specific protease SENP1 has a pro-oncogenic role in several types of cancer (including pancreatic ductal adenocarcinoma (PDAC), prostate cancer, hepatocellular carcinoma, and metastatic neuroblastoma tissues), correlating with poor prognosis61–63. The gene discussed is SUMO1; the disease is prostate cancer.