KLK3 and ductal breast carcinoma in situ: Patients with both invasive cribriform and intraductal carcinoma (n = 79) more frequently had extraprostatic extension (60.8% versus 46.4%; P = 0.02) and lymph node metastasis (11.4% versus 1.6%; P = 0.003) than those with invasive cribriform growth without intraductal carcinoma; there was no statistically significant difference in PSA level (P = 0.07), pT stage (P = 0.64), surgical margin status (P = 0.20), and lymph node metastasis (P = 0.32) between men with combined invasive cribriform and intraductal carcinoma and intraductal carcinoma only.