In addition, all BAP1 domains and motifs, including UCH, CC1, and CTD involved in catalysis as well as DEUBAD domains of ASXLs are targeted by cancer mutations (Supplementary Fig. 11b, c), Finally, we found that a positive BAP1 nuclear staining in mesothelioma tumors, indicative of wild-type BAP146, correlated with positive staining for ASXL2 and UBE2Es, particularly UBE2E2 and UBE2E3, while negative nuclear staining, indicative of BAP1 mutation correlated with negative or reduced (focal) staining for these same proteins. The gene discussed is UBE2E2; the disease is mesothelioma.