Furthermore, since the above-mentioned anti-glioma effects of miR-29a/b/c could be simulated perfectly by the specific siRNAs of TRAF4 and could be partially reversed by TRAF4 overexpression, we conclude that miR-29a/b/c suppress glioma growth at least partly by silencing TRAF4. This evidence concerns the gene TRAF4 and central nervous system cancer.