TRAF4 and central nervous system cancer: To determine whether TRAF4 silencing mediates the adverse effects of miR-29a/b/c on glioma cell proliferation, we transfected the mixture of the miR-29a/b/c-overexpressing sub-cell lines (miR-29s) with the TRAF4-expressing plasmid (miR-29s + TRAF4).