Even within the cohort with similar clinicopathologic features, including tumor grade (Fig. 4e and Supplementary Fig. 6a), IDH gene status (Fig. 4f, g), age, and KPS scores (Supplementary Fig. 6b, c), stratification of the patients according to TRAF4 level could still perfectly reflect the differences in outcomes, i.e., the higher the TRAF4 level, the shorter the OS and DFS of the patients (DFS: P < 0.0001; OS: P < 0.0001). The gene discussed is TRAF4; the disease is neoplasm.