TRAF4 and central nervous system cancer: Additionally, transient knockdown of endogenous TRAF4 with specific siRNAs (P < 0.001; Supplementary Fig. 7c, d) perfectly simulated the suppressive effects of miR-29a/b/c on cell cycle progression and glioma cell proliferation, which were also partially reversed by TRAF4 overexpression (P < 0.01–0.001; Fig. 7a–d).