Toxicity type and onset was not significantly difference between treatment group, including leukopenia (P = 0.189), thrombocytopenia (P = 0.794), haemoglobin reduction (P = 0.176), nausea and vomiting (P = 0.179), diarrhoea (P = 0.203), hearing loss (P = 523), rash (P = 0.414) and alanine aminotransferase (P = 0.125), Likewise, there were no difference between two arms in radiotherapy. This evidence concerns the gene GPT and Thrombocytopenia.