For example, the TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor) deficient MRL-FasLpr mice showed a delayed onset of SLE, and adoptively transferred TACI deficient macrophages alleviated lupus nephritis in wild type MRL-FasLpr mice, all because the TACI deficient macrophages were M2 dominant14. Here, TNFRSF13B is linked to systemic lupus erythematosus.