Meanwhile, as the M1 marker, CD80 was up-regulated in ALD-DNA imitated SLE macrophages (58.17 ± 3.84% vs. 20.10 ± 1.38%, p = 0.000), but depressed after azithromycin treatment (25.9 ± 3.40% vs. 58.17 ± 3.84%, p = 0.000) (Fig. 4b). This evidence concerns the gene CD80 and systemic lupus erythematosus.