Results showed that, after treatment with CDDP for 48 h, cell viability significantly increased in KYSE150 and ECa109 cells with knockdown of RIT1 (Fig. 6a), whereas significantly decreased in KYSE150 and ECa109 cells with overexpressing RIT1 (Fig. 6b), which indicated that RIT1 increased drug sensitivity to CDDP in ESCC cells. The gene discussed is RIT1; the disease is esophageal squamous cell carcinoma.