This can be illustrated by Salmonella infections that only in combination with pre‐mutations allow cellular transformation in tissue culture fibroblasts and gallbladder organoids and is supported by observations of Indian gallbladder cancer patients who showed the corresponding pre‐mutations in the p53 gene, c‐MYC amplification in their tumours and had a history of S. Typhi infection. The gene discussed is TP53; the disease is Salmonella Infections.