IL6 and rheumatoid arthritis: Therefore, and considering the important role of miR-106a, miR-19a-3p, and miR-20a-5pin targeting IL-8 and IL-6 genes and the well-known over-expression of IL-6 and IL-8 in RA synovial tissue, we correlated the expression of IL-6, IL-8, and PDCD4 mRNA with these miRNAs and also with miR-19b-3p and miR-21a-5p that were found to be statistically significant in RA patients.