GPT and Hyponatremia: The most common treatment-emergent grade 3 or 4 AEs with pazopanib were increased alanine aminotransferase (ALT; 12%), increased aspartate aminotransferase (AST; 8%), hyponatremia (5%), lymphocytopenia (5%), hypophosphatemia (4%), hypertension (4%), and diarrhea (4%) [11].