It should also be noted that, although other publications have suggested a link between G-CSF and/or MDSCs and tumor metastasis [64, 80, 84, 85], mice bearing 4T07 tumors, which do not induce visible metastatic lesions [73], produced high levels of G-CSF and more splenic MDSCs than mice bearing any other tumor including highly metastatic 4T1 or 66CL4 tumors. The gene discussed is CSF3; the disease is neoplasm.