The majority of gene sets were down-regulated, and important sets in two lung cancer cells were these involved in cell proliferation, migration, and regulation of apoptosis, angiogenesis, response to hypoxia, canonical Wnt, and toll-like receptor signaling; while adhesion to matrix, response to DNA damage, regulation of epithelial cell differentiation, and histone H3-K9 methylation, were significantly enriched in both A549 and H1299 cells (Fig. 2d), indicating that these pathways are potentially involved in G9a-mediated disease progression lung cancer. This evidence concerns the gene EHMT2 and lung carcinoma.