As shown in Fig. 3a left panel, G9a siRNA significantly decreased the levels of G9a and H3K9-Me2 protien, knockdown of G9a resulted in a significant decrease of in vitro cellular proliferation in three NSCLC cells over 72 h post-transfection of G9a siRNA in comparison with control cells transfected with scramble siRNA (Fig. 3a right panel, P &lt; 0.05). Here, EHMT2 is linked to non-small cell lung carcinoma.