At multivariate Cox regression analysis, BNP value (HR 1.120, [1.001–1.401] CI 95%, p value 0.017), and the GLP-1 RA therapy (HR 0.119, [0.028–0.508] CI 95%, p value 0.004) were predictive of hospitalization for heart failure worsening (Table 4). This evidence concerns the gene GCG and heart failure.