Regard the clinical study outcomes, GLP-1 RA vs. controls patients at follow up end experienced lower rate of hospitalization for heart failure worsening [48 (16.7%) vs. 76 (28.0%), p value < 0.05], higher rate of CRTd responders [193 (67%) vs. 155 (57.2%)], associated to lower number of AF events (23 vs. 41, p value < 0.05), and number of VT events (55 vs. 75, p value < 0.05) (Table 3, Figs. 1, 2, 3 and 4). This evidence concerns the gene GCG and heart failure.