We previously demonstrated that wild type IGFBP4 inhibited IGF1-induced proliferation of microvascular endothelial cells in vitro and that IGF1 increased VEGF production by 4T1.2 mammary adenocarcinoma cells [19], suggesting that dBP4 would have anti-angiogenic effects. The gene discussed is IGFBP4; the disease is breast adenocarcinoma.