NDRG2 and B-cell chronic lymphocytic leukemia: The dual-luciferase assay confirmed that the mimics of miR-28-5p and miR-650 obviously suppressed the activity of NDRG2. In order to understand whether the NDRG2 is a direct target of miR-28-5p and miR-650 in CLL, qRT-PCR was performed to determine the expression of NDRG2, miR-28-5p and miR-650 in 30 CLL patients and 10 HC.