CDH1 and malignant colon neoplasm: Next, Brabletz and colleagues found that the EMT markers E-cadherin and β-catenin exhibited different expression patterns at the invasive front and central areas of the primary tumors in colorectal cancer in 2001, subsequently, accumulating evidences suggested that EMT occurred at the invasive front and produced single migratory cells to promote colon cancer metastasis, especially liver metastasis, and finally led to poor prognosis [16–18].