Identifying RUNX1 as a regulator of HTR2B gene expression in UM cancer cells is particularly relevant to our study in that deregulation of this TFs appears to be a characteristic of many types of cancers, including acute leukemia (reviewed in [43]), human colorectal [44], prostate [45], endometrial, ovarian [46], and human skin and oral squamous cell carcinomas [47]. The gene discussed is RUNX1; the disease is cancer.