ACHE and leukemia: Sarcophine (3), a major metabolite of soft corals, exhibits a myriad of bioactivities as follows: Toxicity to fish, mice, rats, and guinea pigs [32]; inhibition of acetylcholinesterase and phosphofructokinase [32,33]; cytotoxicity against leukemia HL-60 [25]; suppression of cellular transformation [34]; inhibition of migration and wound healing [35,36]; and impairment of DNA repair by the formation of DNA adducts [37].