MTOR and cancer: Here, we focus on mammalian/mechanistic target of rapamycin (mTOR) complexes, essential regulator of cell proliferation and metabolism, as a potential key player to play a role in sensing nutrients to drive the intracellular tumor-promoting signaling cascade through metabolic reprogramming and epigenetic shift, and a key node which should be therapeutically targeted as a new mode of treatment to interfere with cancer cell metabolism.