SAMTOR and cancer: Notably, the methyl donor S-adenosylmethionine (SAM) disrupts the SAMTOR-GATOR1 complex, and methionine-induced activation of mTORC1 requires the SAM binding capacity of SAMTOR, indicating that mTORC1 is involved in methionine and one-carbon metabolism, which potentially control the epigenetic (methylation) shift in cancer.