mTOR complex 1 (mTORC1), an established druggable target against cancer, phosphorylates and controls its substrates p70 ribosomal protein S6 kinase 1 (S6K1) and eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) to promote protein translation as well as anabolic metabolism downstream of growth factor receptor-activated PI3K-Akt signaling [19,20]. This evidence concerns the gene PIK3CA and cancer.