NFKB1 and neoplasm: In addition, NF-κB is known to regulate the transcription of a number of anti-apoptotic genes including BCL2, BCLXL, BCL2 family member 1/anti-apoptosis protein 1 (BFL1/A1) as well as inhibitor of apoptosis proteins (IAPs) and the caspase-8 regulating protein c-FLIP [142,143,144,145], again supporting the development and/or maintenance of those cancer hallmarks associated with tumour survival.