This is supported by Park who reported that IKKα is involved in regulation of oestrogen-dependent genes such as cyclin D1 and c-myc, which also control cell proliferation [39] and Dan demonstrates that IKKα via mTORC can induce cell proliferation in cervical, lung, prostate and pancreatic cell lines [78] and in basal cell carcinoma IKKα is associated with proliferation and EMT [93]. Here, CHUK is linked to basal cell carcinoma.