The transcriptional modulation driven by IKKα-mediated signalling, divulged using a number of experimental approaches such as genetic deletion and reconstitution [48,49], siRNA ‘run-down’ [35] and over-expression strategies [50], may be in excess of 200 genes and these gene/protein induction/repression events support the acquisition of characteristics of specific ‘hallmarks’, particularly the ability of tumours to ‘sustain proliferative signalling’, ‘resist cell death’, ‘evade growth suppressors’ and encourage ‘genomic instability and mutation’. The gene discussed is CHUK; the disease is neoplasm.