Drugs like corticosteroids, antihistamines, leukotriene modifiers, anticholinergics, β-agonists, and anti-IgE preparations are effective at controlling the symptoms of allergy, however, reducing the relapse of AD remains a worldwide problem, which prompts us to further investigate the pathological mechanism of AD and find new therapeutic targets against it [7,8]. Here, IGHE is linked to Alzheimer disease.