AKT1 and ovarian cancer: Therefore, Kala et al. (2014) designed a combination of a triethanolamine-core PAMAM dendrimer which forms stable NPs with the Akt siRNA, can protect the siRNA against RNase digestion and is highly effective for initiating Akt target-gene silencing both in vitro and in vivo; administration of dendrimer-nanovector-mediated siRNA delivery to target Akt, combined with PTX to target cancer cells, shows potentially effective and potent anticancer activity in ovarian cancer [118].