TFRC and neoplasm: Regarding liposome-mediated therapy, various strategies have been adopted for passive targeting of liposomes to the tumor sites by using PEG and active targeting of cancer cell surface receptors, FRs, TfR and EGFRs and the tumor microenvironment including VEGF, VCAM, matrix metalloproteases, αβ-integrins and surface grafting of liposomes with aptamers [34].