Another crossover study found that compared with EPA alone, EPA + DPA supplementation could significantly lower TAG, TC, non-high-density lipoprotein cholesterol, very low-density lipoprotein cholesterol (VLDLC), ApoC3, and proprotein convertase subtilisin kexin type 9 (PCSK9) in subjects with severe hypertriglyceridemia [56]. This evidence concerns the gene PCSK9 and hypertriglyceridemia.