Furan fatty acids may also have an anti-inflammatory effect: The New Zealand green lipped mussel contains a certain amount of furan fatty acids [32], and our previous RCT indicated a lipid extract from mussels effectively improved clinical conditions of patients with rheumatoid arthritis, significantly decreased levels of tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β) and prostaglandin E2 (PGE2), and significantly increased levels of IL-10 [39]. The gene discussed is TNF; the disease is rheumatoid arthritis.