Although multiple molecular targets including Sirt-1, AMPK, Nrf2, and NF-κB, have been identified to play an important role in the health benefits of resveratrol against cardiovascular diseases, one of the key cardioprotective mechanisms is the ability of resveratrol to scavenge free-radicals [81] and increase the bioavailability of NO [82]. The gene discussed is NFKB1; the disease is cardiovascular disorder.