PTEN and cancer: Several studies indicate that curcumin and its analog can suppress the expression of miR-21, cyclin D1, and antigen Ki-67, but enhance the expression of phosphatase and tensin homolog (PTEN), programmed cell death protein 4 (PDCD4), and miR-21 target genes, resulting in induced apoptosis and antiproliferation in cancer cells [95,96].