For PD, increasing evidence indicates that the accumulation of α-synuclein protein plays a vital role in the occurrence of PD [143], suggesting that curcumin can reduce the accumulation of A53T α-synuclein by downregulating the mTOR/ribosomal protein S6 kinase (p70S6K) signaling, and restoring macroautophagy. Here, RPS6KB1 is linked to Parkinson disease.