PTGS2 and neuroblastoma: In addition, pretreatment with curcumin shows an anti-inflammatory effect against the colistin-induced toxicity in neuroblastoma-2a cells, as it significantly downregulates the expression of the pro-inflammatory mediator cyclooxygenase-2 (COX-2), blocks the phosphorylation of IκB, and concomitantly decreases the NF-κB level [52].