We targeted here the expression of EMMPRIN in carotid atherosclerosis, providing evidence that the use of non-invasive strategies with theranostic potential, narrowing specific molecules involved in atherosclerosis like EMMPRIN, may have a significant impact when it comes to future improvement in the precision of diagnostic and management of coronary artery diseases, including coronary atheroma plaque vulnerability or acute coronary syndrome, with promising implications in the future of clinical practice focused on the prevention, diagnostic and follow up progression of disease. This evidence concerns the gene BSG and carotid atherosclerosis.