Such is the case of the recent finding in which disruption of the MCT-4/EMMPRIN complex by a small molecule termed Acriflavine, inhibits the hypoxic response, proliferation, and tumor progression in glioblastoma cells [23], or the cardioprotective effect of NO in acute myocardial infarction in which the complex Caveolin-3/low-glycosylated EMMPRIN is stabilized by NO, thus preventing EMMPRIN glycosylation [20]. This evidence concerns the gene BSG and glioblastoma.