APOE and atherosclerosis: To test whether EMMPRIN was also expressed in carotid atherosclerotic plaques, we found extensive co-localization of EMMPRIN with CD68 positive infiltrated macrophages in NOS3/apoE double KO mice, when compared to NOS3-expressing animals (Figure 2C), indicating that EMMPRIN is a target of carotid inflammation in atherosclerosis.