Interestingly, the combined assessment of antioxidant activity, assessed as serum paraoxonase-1 (PON1), an enzyme that protects against lipid peroxidation, and inflammation, measured as monocyte migration by circulating (C-C motif) ligand 2 (CCL2), differentiated PAD patients from controls almost perfectly [66]. This evidence concerns the gene PON1 and peripheral arterial disease.