Conversely, the Bcl-2 levels were significantly greater (by 40%) in the HFD + EX group than in the HFD group (p < 0.05, Figure 3B), suggesting that aerobic exercise training for 12 weeks protected against obesity-induced early mitochondria-mediated apoptotic signaling. Here, BCL2 is linked to obesity due to melanocortin 4 receptor deficiency.