In the animal model of both T1DM (streptozotocin) and T2DM (db/db mouse), increased miR-195 reduced SIRT-1 levels in mouse hearts, whilst knocking down miR-195 expression, decreasing oxidative stress, increasing myocardial capillary density and improving maximal coronary blood flow [62]. Here, SIRT1 is linked to type 1 diabetes mellitus.