NOD2 and Autoimmunity: To address the role of microbe-derived molecules in the patho-etiology of autoimmunity, normal mice were stimulated repeatedly with a broad range of pathogen-associated molecular patterns (PAMPs) (PG, TLR-2 ligand; LTA, TLR-2 ligand; MDP, NOD-2 ligand; LPS, TLR-4 ligand).