In our study, the increased expression of TIMP-1, CXCL1, MCP-1, MIP-2, and IL-1ra was strongly associated with RT-induced lung fibrosis through the induction of alternatively activated macrophages and neutrophils [37,38,39,40,41,42,43,44,45]. The gene discussed is CXCL1; the disease is pulmonary fibrosis.