Cancer cells that encounter a combination of different signaling molecules like PDGF [51], HGF [52], TGF-β1 [49,53], or EGF [54] among many others secreted by the complex tumor microenvironment orchestrate the gene expression of cancer cells for instance by upregulation of transcription factors like snail, twist, or zeb1 [55]. This evidence concerns the gene ZEB1 and neoplasm.