A wide variety of neurological diseases are characterized by the accumulation of iron in different areas of the central nervous system; these diseases include Parkinson’s disease (PD) and other parkinsonisms such as Lewy bodies dementia, progressive supranuclear palsy, corticobasal degeneration [16,17,18,19,20,21], the Westfal variant of Huntington disease [22], Alzheimer’s disease (AD) [23,24,25,26,27], Friedreich’s ataxia [28], pantothenate kinase-associated neurodegeneration [29,30,31] and other neuropathologies associated with brain iron accumulation [32,33,34]. Here, PANK1 is linked to early-onset autosomal dominant Alzheimer disease.